Disulfide-linked Homodimer (2 x 109 amino acid subunits)
Target Receptor
Activin type IIB receptor (ActRIIB)
Molecular Weight
~25.0 kDa (25,000 g/mol)
Purity
≥ 98.0% (Verified by SDS-PAGE & HPLC)
Biological Activity
Fully Active (Inhibits skeletal muscle growth in vitro/in vivo)
Appearance
White Lyophilized Powder
Storage
Store at -20°C to -80°C (Protect from light and moisture)
🛑
What is GDF-8 (Myostatin)?
GDF-8 (Growth Differentiation Factor 8), universally known as Myostatin, is a complex recombinant homodimer protein that acts as the body’s ultimate “brake” on skeletal muscle mass. Supplied in massive 1mg x 10 Vials research kits, it is not a muscle builder; it is the exact opposite. GDF-8 is the highly specific, active ligand that binds to the ActRIIB receptor to aggressively halt muscle tissue proliferation and induce atrophy. For top-tier laboratories, this active recombinant protein is an absolutely indispensable Core Control Substance. It is primarily utilized to construct severe muscular atrophy models in vitro, or to screen, validate, and quantify the neutralizing power of experimental Myostatin Inhibitors like ACE-031, Follistatin 344, and specific monoclonal antibodies.
Key Features & Research Protocols
⚖️
The Ultimate Muscle Brake
Functions as the primary negative regulator of myogenesis. It actively halts the proliferation and differentiation of myoblasts (muscle stem cells), placing a strict genetic limit on tissue size.
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Core Antagonist Screening
The gold standard for inhibitor assays. Researchers must apply this active GDF-8 to cell cultures to verify if experimental decoy receptors (like ACE-031) successfully neutralize its binding capability.
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In-Vitro Atrophy Modeling
Utilized to artificially induce the Smad2/3 signaling cascade in laboratory settings, perfectly mimicking the muscle-wasting environments seen in severe cachexia and muscular dystrophy.
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Complex Homodimer Structure
Unlike simple peptides, this is a fully folded, disulfide-linked homodimer (~25.0 kDa). This complex 3D structure is absolutely critical to guarantee a high-affinity lock onto the ActRIIB receptor.
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Receptor Binding Analysis
Provides an essential pure ligand for advanced surface plasmon resonance (SPR) or ELISA testing, allowing scientists to measure precise binding kinetics in muscle signaling pathways.
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Verified Biological Activity
Purified to ≥98.0% and rigorously validated for full biological activity. Guaranteed to suppress cellular proliferation in standard bioassays to ensure reproducible research data.
How It Works: The TGF-β Superfamily Cascade
To defeat an enemy, you must fully understand its weapons. GDF-8 (Myostatin) is a prominent member of the Transforming Growth Factor-beta (TGF-β) superfamily. In a living organism, it is secreted primarily by skeletal muscle cells, circulating in the blood as a sentinel against unchecked muscle growth.
The mechanism of GDF-8 is terrifyingly efficient. The active, mature GDF-8 homodimer seeks out and binds with extreme affinity to the Activin type IIB receptor (ActRIIB) located on the surface of muscle cells. Once the connection is made, it recruits a type I receptor (ALK4 or ALK5), triggering a massive intracellular cascade.
This binding phosphorylates (activates) the Smad2 and Smad3 proteins inside the cell. These proteins then travel directly into the cell’s nucleus, where they act as powerful transcription factors. They actively suppress the genes responsible for muscle growth (like MyoD and myogenin) while simultaneously upregulating genes that break down muscle proteins. In advanced research, supplying pure GDF-8 allows scientists to intentionally activate this “self-destruct” pathway. By flooding a model with GDF-8, researchers can precisely measure how effectively compounds like ACE-031 (which acts as a decoy to trap GDF-8) or Follistatin (which directly binds and neutralizes GDF-8) can rescue the muscle cells from this artificially induced atrophy.
🧪 What’s In The Kit
Active Compound: GDF-8 (Myostatin) Recombinant Protein
Format: 10-Vial Research Kit
State: Sterile, Lyophilized Powder
Net Contents: 1mg per vial (10mg total)
Purity: ≥98.0% (Verified by SDS-PAGE)
👩🔬 Who Uses It
Muscular Dystrophy Researchers
Biotech Drug Discovery Labs (Inhibitor screening)
Cellular Biology & Signaling Investigators
Spaceflight Muscle Atrophy Analysts
Cachexia & Wasting Disease Specialists
🔗 Best Paired With (For Assays)
ACE-031 (Decoy Receptor) – For neutralization testing
Follistatin 344 – For direct binding assays
Specific Cell Culture Media (e.g., DMEM)
Western Blot / ELISA analysis kits
As Mentioned On
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