Direct neutralization of Myostatin (GDF-8) and Activin A
Molecular Weight
~34.8 kDa (34,800 g/mol)
Purity
≥ 98.0% (Verified by SDS-PAGE & HPLC)
Appearance
White Lyophilized Powder
Storage
Store at -20°C to -80°C (Protect from light and moisture)
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What is Follistatin 344?
Follistatin 344 (FST-344) is a sophisticated single-chain recombinant glycoprotein universally acclaimed in advanced biology as the definitive **Muscle Growth Amplifier**. Supplied in massive 1mg x 10 Vials research kits, Follistatin 344 is an unprecedented tool for investigating the limits of skeletal muscle hypertrophy. Unlike generic muscle builders, its mechanism is purely antagonistic: it functions as a potent, direct neutralizer of both **Myostatin (GDF-8)** and **Activin A**. By physically binding to and “locking down” these powerful negative regulators of muscle growth, Follistatin 344 allows for unhindered satellite cell proliferation and differentiation, providing a unique research model to observe the unlocking of a tissue’s genetic upper limit for skeletal mass accumulation.
Key Features & Research Protocols
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Hypertrophy Amplifier
Functions as the body’s ultimate “unlocking” molecule. By neutralizing Myostatin, it dramatically amplifies the growth signaling in skeletal muscle tissue, allowing for rapid and profound cellular hypertrophy.
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Physical Neutralization
Designed for direct combat. It doesn’t compete for receptors; instead, it physically surrounds and binds to GDF-8 (Myostatin) with extreme affinity, rendering the inhibitory ligand completely inactive.
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Unlocking Genetic Limits
Provides a groundbreaking research model for observing tissue development completely stripped of its natural growth brakes (Myostatin/Activin A), revealing the pure, uninhibited genetic potential for skeletal mass growth.
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Activin A Neutralization
Possesses a critical dual-action. Beyond Myostatin, it also neutralizes Activin A, another key TGF-β family member that contributes to muscular atrophy, systemic inflammation, and cachexia (wasting).
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Complex Glycoprotein
This is a fully-folded, 344-amino-acid single-chain glycoprotein (~34.8 kDa). Its complex 3D structure and specific glycosylation patterns are absolutely critical for guarantee high-affinity neutralization of GDF-8.
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Verified High Purity
Purified to ≥98.0% and validated via SDS-PAGE and HPLC. Highly stable in lyophilized powder form, ensuring reproducible and precise biological data in critical cell culture and in vivo hypertrophy research.
How It Works: The Pure Physical Neutralizer
To understand the nuclear power of Follistatin 344 (FST-344), you must contrasts its mechanism with ACE-031. ACE-031 is a decoy; it tricks Myostatin into binding to it, rather than the real muscle cell receptor. Follistatin 344 does not trick the enemy; it physically eliminates it from the battlefield.
Follistatin 344 is a complex, fully active glycoprotein designed specifically to counteract members of the Transforming Growth Factor-beta (TGF-β) superfamily. Its most critical target is **GDF-8 (Myostatin)**, the cellular “stop sign” that halts the proliferation of satellite cells (muscle stem cells) and prevents differentiation into mature muscle fibers.
The mechanism is beautifully and brutally efficient. When introduced to a muscle environment, the Follistatin 344 molecule possesses a ferocious physical affinity for GDF-8. It doesn’t wait for GDF-8 to find a receptor; instead, it actively seeks out the mature Myostatin ligand and tightly binds to it, effectively creates a molecular “straightjacket.” Once “embraced” and locked by Follistatin, the Myostatin molecule is physically neutralized. It is rendered structurally unable to bind to its target **ActRIIB receptor** on the muscle cell surface. By stripping away this ubiquitous negative regulator, Follistatin 344 eliminates the cellular Smad2/3 “atrophy” signaling, thereby allowing the natural anabolics pathways (such as Akt/mTOR) to become supercharged. This creates a highly explosive anabolic environment where satellite cells divide and muscle mass accumulates at an accelerated and unchecked rate, unlocking the true biological potential of skeletal tissue growth.
🧪 What’s In The Kit
Active Compound: Follistatin 344 (Recombinant Protein)
Format: 10-Vial Research Kit
State: Sterile, Lyophilized Powder
Net Contents: 1mg per vial (10mg total)
Purity: ≥98.0% (Verified by SDS-PAGE)
👩🔬 Who Uses It
Extreme Hypertrophy Investigators
Biotech Drug Discovery Labs (Inhibitor screening)
Cachexia & Wasting Disease Specialists
Muscular Dystrophy Researchers
Cell Signaling Pathway analysts (Akt/mTOR)
🔗 Best Paired With (For Assays)
Sterile Bacteriostatic Water (BAC)
DMEM / Specialized Cell Culture Media
GDF-8 (Myostatin) Protein – For neutralization validation
Western Blot / ELISA detection kits
As Mentioned On
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TrustScore 4.9 | 129 reviews
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